Software - Breakage-fusion-bridge (BFB)

Breakage-fusion-bridge (BFB) is a mechanism of genomic instability characterized by the joining and subsequent tearing apart of sister chromatids.

When this process is repeated during multiple rounds of cell division, it leads to patterns of copy number increases of chromosomal segments as well as fold-back inversions where duplicated segments are arranged head-to-head.

This software (BFB) facilitates the analysis of BFB mechanism in genomes.

Citation: Zakov, Shay, Marcus Kinsella, and Vineet Bafna. "An algorithmic approach for breakage-fusion-bridge detection in tumor genomes." Proceedings of the National Academy of Sciences 110.14 (2013): 5546-5551.

Paper: http://www.pnas.org/content/110/14/5546.full

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(1)  BFB data

(2)  Activation mode

(3)  Error model

(4)  Max error

(0 < number < 1)