Cancer epigenomics: DNA methylomes and histone-modification maps

 At 2014-02-25 08:05:13 PM  |   365

An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis; among their results has been the seminal finding of transcriptional silencing of tumour-suppressor genes by CpG-island-promoter hypermethylation. Read more

STAR: an integrated solution to management and visualization of sequencing data

 At 2013-11-11 04:05:43 PM  |   441

STAR represents a next-generation data exploration solution to match the requirements of NGS data, enabling both intuitive visualization and dynamic analysis of data. Read more