Bioinformatics Education - Summer school in Bioinformatics July 25-30 IN HOCHIMINH CITY, VIETNAM

 At 2015-07-01 04:53:02 PM  |   76

Within the last 10 years, with the new development of Genome Sequencing methods, biotechnology has been in its revolution: many diseases has been detected and cured using the information from patients’ DNA; many new cells and their functions have been discovered based on single cell sequencing; many efficients drugs/vaccines been designed using the genomic information of viruses and human. Read more

Human Genetics - Genomic Medicine Conference - Print and post the conference flyer at your institution/university

 At 2015-04-20 02:14:43 PM  |   98

Genomic Medicine Conference, July 20-22, 2015, Vietnam. Program Committee, Invited Speakers: Ron Shamir, Serafim Batzoglou, Pavel Pevzner, Mike Brudno, Vineet Bafna, Ben Raphael, Paul Medvedev, Michael Beer,...  Read more

Human Genetics - Genomic Medicine Conference - Paper and abstract submission deadline

 At 2015-04-20 01:47:05 PM  |   76

Genomic Medicine Conference, July 20-22, 2015, Vietnam. Program Committee, Invited Speakers: Ron Shamir, Serafim Batzoglou, Pavel Pevzner, Mike Brudno, Vineet Bafna, Ben Raphael, Paul Medvedev, Michael Beer,... Read more

Human Genetics - Genomic Medicine 2015 - From 20 - 23 July 2015, HoChiMinh City, Vietnam

 At 2015-02-26 08:38:05 PM  |   456

Genomic Medicine 2015! 20 - 23 July 2015, HoChiMinh City Genomic Medicine Conference is devoted to the latest advances in the use of omics data in medical practice. Read more

Human Genetics - Networks Reveal the Connections of Disease

 At 2015-02-24 01:32:49 PM  |   190

Enormous databases of medical records have begun to reveal the hidden biological missteps that make us sick. Read more

Genome Assembly - From Indexing Data Structures to de Bruijn Graphs

 At 2014-10-31 03:03:42 PM  |   286

New technologies have tremendously increased sequencing throughput compared to traditional techniques, thereby complicating DNA assembly. Read more

Microbial Genomics - Ragout—a reference-assisted assembly tool for bacterial genomes

 At 2014-06-16 01:38:04 PM  |   152

Bacterial genomes are simpler than mammalian ones, and yet assembling the former from the data currently generated by high-throughput short-read sequencing machines still results in hundreds of contigs. To improve assembly quality, recent studies have utilized longer Pacific Biosciences (PacBio) reads or jumping libraries to connect contigs into larger scaffolds or help assemblers resolve ambiguities in repetitive regions of the genome. Read more

Single Cell Genomics - Genome yields insights into golden eagle vision, smell

 At 2014-06-08 01:19:29 PM  |   114

Purdue and West Virginia University researchers are the first to sequence the genome of the golden eagle, providing a bird's-eye view of eagle features that could lead to more effective conservation strategies. Read more

Bioinformatics Education - The higher-resolution versions of the lecture videos for Bioinformatics Algorithms

 At 2014-04-22 08:25:20 PM  |   78

The higher-resolution versions of the lecture videos for Bioinformatics Algorithms Read more

Cancer Genomics - Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.

 At 2014-03-28 02:38:21 AM  |   95

Whole-genome sequencing is becoming increasingly available for research purposes, but it has not yet been routinely used for clinical diagnosis. Read more

Human Genetics - Genetic and functional properties of uncultivated MCG archaea assessed by metagenome and gene expression analyses

 At 2014-03-18 02:05:18 AM  |   95

The Miscellaneous Crenarchaeota group (MCG) Archaea is one of the predominant archaeal groups in anoxic environments and may have significant roles in the global biogeochemical cycles. However, no isolate of MCG has been cultivated or characterized to date. In this study, we investigated the genetic organization, ecophysiological properties and evolutionary relationships of MCG archaea with other archaeal members using metagenome information and the result of gene expression experiments. Read more

Bioinformatics Education - Epigenetic Control of Gene Expression

 At 2014-03-18 02:01:05 AM  |   328

Each mammalian cell has the same genes, yet performs distinct functions. This is achieved by epigenetic control of gene expression; the switching on and switching off of genes. This course will cover the principles of epigenetic control of gene expression, how epigenetic control contributes to cellular differentiation and development, and how it goes wrong in disease. Read more

Comparative Genomics - Initial sequencing and comparative analysis of the mouse genome

 At 2014-03-16 02:40:49 AM  |   95

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome.  Read more

RNA-SEQ - Comparative analysis of RNA sequencing methods for degraded or low-input samples

 At 2014-03-09 08:36:46 AM  |   209

RNA-seq is an effective method for studying the transcriptome, but it can be difficult to apply to scarce or degraded RNA from fixed clinical samples, rare cell populations or cadavers. Recent studies have proposed several methods for RNA-seq of low-quality and/or low-quantity samples, but the relative merits of these methods have not been systematically analyzed.  Read more

Microbial Genomics - An environmental bacterial taxon with a large and distinct metabolic repertoire

 At 2014-03-06 11:04:16 AM  |   76

Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such ‘talented’ producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic diversity. The uncultured majority is generally perceived as a large, untapped resource of new drug candidates, but so far it is unknown whether taxa containing talented bacteria indeed exist. Read more

Neuroscience - Focus on pain

 At 2014-03-05 07:27:23 PM  |   273

Pain can be defined simply as the subjective experience of harm in a part of one's body. In reality, however, there are multiple forms of pain, which involve a variety of distinct biological processes. Exposure to extreme heat, cold or pressure can be noxious, triggering nociceptive pain. Inflammatory pain, involving the release of cytokines and the infiltration of immune cells, also occurs subsequent to injury, but can be triggered independently by bacterial infections. Although pain has an important physiological role in preserving the integrity of the body, pathological pain also exists. Nerve damage, in surgery patients for instance, sometimes leads to chronic pain conditions that can last years or even decades. Read more

Microbial Genomics - Biogenesis and functions of bacterial S-layers

 At 2014-03-01 08:20:03 PM  |   159

The outer surface of many archaea and bacteria is coated with a proteinaceous surface layer (known as an S-layer), which is formed by the self-assembly of monomeric proteins into a regularly spaced, two-dimensional array. Bacteria possess dedicated pathways for the secretion and anchoring of the S-layer to the cell wall, and some Gram-positive species have large S-layer-associated gene families. Read more

RNA-SEQ - Highly Multiplexed Subcellular RNA Sequencing in Situ

 At 2014-02-27 11:37:08 PM  |   152

Scientists can now take snapshots of where and how thousands of genes are expressed in intact tissue samples, ranging from a slice of a human brain to the embryo of a fly. Read more

Genome Assembly - De novo genome assembly: what every biologist should know

 At 2014-02-27 07:24:38 AM  |   304

Asked how mature the field of genome assembly is, Ian Korf at the University of California, Davis, compares it to a teenager with great capabilities. “It's got bold assertions about what it can do, but at the same time it's making embarrassing mistakes,” he says. Perhaps the biggest barrier to maturity is that there are few ways to distinguish true insight from foolish gaffe. When a species' genome is newly assembled, no one knows what's real, what's missing, and what's experimental artifact. Read more

Cancer Genomics - The genomic complexity of primary human prostate cancer

 At 2014-02-26 09:14:25 PM  |   63

Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence of seven primary human prostate cancers and their paired normal counterparts. Several tumours contained complex chains of balanced (that is, ‘copy-neutral’) rearrangements that occurred within or adjacent to known cancer genes. Rearrangement breakpoints were enriched near open chromatin, androgen receptor and ERG DNA binding sites in the setting of the ETS gene fusion TMPRSS2–ERG, but inversely correlated with these regions in tumours lacking ETS fusions.  Read more